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Showing posts with label CANCER. Show all posts
Showing posts with label CANCER. Show all posts

Tuesday, March 13, 2012


India's first compulsory licence granted to Natco for Bayer's cancer drug

source: The hindubusinessline

   
Hyderabad firm to sell the drug at Rs 8,880/month; to pay Bayer 6% of net sales as royalty


The country's first compulsory licence has been granted by the Indian Patent Office to Hyderabad-based drug-maker Natco.
A landmark decision, under the amended Indian Patents Act (2005), allows Natco to make and sell in India, a similar version of Bayer's Nexavar, an advanced kidney cancer drug.
Natco will have to pay Bayer royalty pegged at six per cent of net sales, every quarter. Buoyed by the development, Natco shares closed up 6 per cent on the BSE, on Monday.

Landmark judgment

The 62-page judgment is Mr P. H. Kurian's last as the Patent Controller. The judgment reasoned that the patent-holder, Bayer, had not met the reasonable requirement of the public. It had not “worked the patent” or manufactured it to a reasonable extent in India. Besides, the drug was not available at an affordable price.

Compulsory licence

A compulsory licence (CL) is granted by a country on health grounds, where patients are unable to access a life-saving medicine.
Bayer imported the product, and while its global sales of Nexavar was $934 million in 2010, in India it clocked sales of Rs 16 crore in 2009, the judgment said. The figures demonstrate “neglectful conduct” of the patentee (Bayer) in India, the judgment added.
Only 2 per cent of the 8,842 patients needing the drug got the medicine, it observed. The patients needing the drug “far exceed” the supply of the product, he added.

Bayer reaction

A Bayer spokesperson, however, said: “We are disappointed by the decision of the Patent Controller in India to grant a compulsory licence for Nexavar. We will evaluate our options to further defend our intellectual property rights in India.”
Cipla too sells its version of generic Nexavar in India, from April 2010.
But Bayer had subsequently taken them to the Delhi High Court over patent-infringement.
On Monday, Mr Kurian also handed over charge at the Patent office to Mr Chaitanya Prasad.
Our Hyderabad bureau adds: Dr P. Bhaskara Narayana, Chief Financial Officer, Natco, said the market for the product was around Rs 30 crore a year. The company will begin selling the drug after a stay granted by the Delhi High Court is vacated.
“The stay will be vacated once we submit the order of the Controller General of Patents Designs and Trademarks to the High Court,” he said.
“We welcome this order as it opens up a new avenue of availability of life-saving drugs at an affordable price to the suffering masses in India,” he said. Natco also expects the market for the drug to expand now, though it might come down in value terms.

Saturday, February 5, 2011

Let us join hands to fight cancer

by S.M. Chandramohan
 
Each year 127 lakh people discover that they have cancer and of them, 76 lakh die. Two-thirds of these distressing deaths occur in low and middle income countries.
The World Health Organization projects that unless immediate action is taken, deaths from cancer will increase by nearly 80 per cent by 2030; most of them occurring in low and middle income countries. That translates to nearly 260 lakh newly diagnosed cases and about 170 lakh deaths every year! In fact, cancer kills more people than do AIDS, malaria and tuberculosis combined.
Research suggests that “one-third of cancer deaths can be avoided through prevention” and “one-third through early detection and treatment”. The Union for International Cancer Control (UICC) states that the world's cancer burden is rising and, without action, the poorest countries — those currently least equipped to cope — will witness the largest increases in mortality by 2015. As per the UICC, whose headquarters is in Geneva, Switzerland, the number of deaths due to cancer every year is more than the population of the whole of Switzerland.
There are so many known causes acting directly or indirectly on the systems to produce cancer. Many of them are related to “lifestyle” and avoiding these can prevent or protect against cancer.
Measures to prevent cancer include eschewing tobacco, having good dietary habits, physical activity, maintaining a healthy diet, environmental health, prevention of cancer causing infections and limiting alcohol intake.
Tobacco
Many people relate tobacco to cardiac and respiratory diseases. But beyond that, smoking is the single biggest cause of cancer in the world. It is responsible for more than 25 per cent of all cancer deaths; it kills one person every six seconds.
It also accounts for one in 10 adult deaths and kills more than 50 lakh people every year.
Smoking not only affects the person who smokes but also people around him through second-hand smoke. Children born to mothers who smoke are also affected.
The risk of oral cancer increases 27 fold in men and six fold in women who smoke. Laryngeal cancer is 10 times more common in men and eight times more common in women. There is an eight to 10 fold increase in oesophageal cancer and 50 per cent increase in gastric cancer in tobacco users compared to non-smokers.
It has been noticed that there is a two-fold increase in pancreatic cancer among smokers. If they smoke more than 40 cigarettes a day, there is a five-fold increase.
The risk increases significantly if the individual has the habit of drinking also.
In many situations we find that many cancer patients have been smoking and drinking for years.
Diet
This is a factor that concerns everyone. Diet plays a significant role in the prevention of certain cancers, not necessarily in the Gastro-Intestinal system.
A “Healthy Diet” can prevent many cancers, more so if it is combined with physical activity. Many medical societies fighting cancer recommend the following:
— Be as lean as possible without becoming underweight
— Be physically active for at least 30 minutes every day
— Avoid sugary drinks
— Eat plenty of vegetables, fruits, whole grains and pulses
— Limit consumption of red meat and avoid processed meat
— Limit consumption of alcohol
— Limit salty food
It is also better to avoid reheated oil for cooking.
Cancer-causing infections
An estimated 22 per cent of cancer deaths in the developing world and six per cent of deaths in industrialised countries are related to cancer-causing infections.
Significant among these are Human Papilloma Virus causing cancer of the cervix and Hepatitis B and C causing liver cancer.
Environmental carcinogens
Environmental factors do play a role in certain cancers; poor air quality indoors and chemical pollutants can cause lung cancer. Similarly, food chemicals can be responsible for gastro-intestinal cancers.
Research done by the Department of Surgical Gastroenterology, Rajiv Gandhi Government General Hospital, along with the Department of Clinical Nutrition, Ethiraj College for Women, on gastric cancer produced revealing insights.
Of 100 patients analysed, 98 had the habit of consuming preserved food in the form of leftover rice, dried fish, pickle, or — for a majority — a combination of leftover rice and pickle. Moreover, 97 patients had the habit of reusing oil — 77 people reused oil more than three times; 88 were non-vegetarians; 78 consumed 25-30 grams of salt per day; and 74 consumed about 20 grams of chilli in their meal every day. In addition, 73 were smokers, 37 had the habit of tobacco chewing, 33 consumed alcohol every day, only 21 had the habit of exercising, and only two out of 100 consumed fresh fruits and vegetables regularly.
Indian scenario
As per results published by the Tumour Registry, in men, lung cancer tops the list followed by cancers of the stomach, oral cavity, oesophagus and oro-pharynx.
In women, breast cancer leads, followed by cancer of the cervix, ovary, oral cavity and stomach. Also, if reproductive organs are excluded, stomach cancer is the second most common cancer affecting people living in Tamil Nadu.
Similarly, oesophageal cancer is the fourth most common in men and in women [third if reproductive organs are excluded]. As per a publication by the Registry in 2010, cancers from the oral cavity to the stomach constitute 25.4 per cent of all cancers in men and 14.4 per cent in women.
Of these “Tobacco Related Cancers” — namely cancers of the oral cavity, oro-pharynx, larynx, lung, oesophagus, pancreas and urinary bladder — constitute 44 per cent of all cancers in men and 16 per cent in women.
What is being done ?
The Union for International Cancer Control is aiming for a “World Cancer Declaration”. The declaration outlines 11 targets to be achieved by 2020, which include:
— Significant drop in global tobacco consumption, obesity and alcohol intake
— Universal vaccination programmes for Hepatitis B and Human Papilloma Virus to prevent liver and cervical cancer
— Universal availability of effective pain medication and
— Dispelling myths and misconceptions about cancer
Every year February 4 is observed with a focus and for 2011 it is “teach children and teenagers to avoid UV exposure by being “Sun Smart.”
What do we have to do?
It is a common observation that many people in our society present cancer at an advanced stage. Various studies done across India shows that 60-70 per cent of the patients present at an advanced stage where cure may be impossible.
The main factors which contribute to this include: Myths and misconception about cancer, lack of awareness, negligence and dietary and lifestyle modifications including tobacco use and regular consumption of preserved foods.
The major task before the health authorities is to create awareness, dispel myths and misconceptions and provide the best advice to people on healthy lifestyle, eating habits and the need for exercise. More importantly, people should not “ignore the symptoms” and must consult a doctor to get the appropriate treatment without delay. All of us can play a role to create a cancer-free world. You need not to be a doctor to spread this message. Let us all join hands to fight against cancer.

(The writer is Head of the Department of Surgical Gastroenterology, Centre of Excellence for Upper GI Surgery, Rajiv Gandhi General Hospital and Madras Medical College, Chennai.)

World Cancer Day is an occasion to dispel myths and spread awareness of cancer.

Sunday, April 11, 2010

positive message from a cancer survivor

by R. Sujatha

The part time consultant counsellor and head of cancer support groupin Apollo Speciality Hospital, Teynampet, shares her experiences as a cancer survivor and a counsellor with R.Sujatha.

Even before Neerja Malik can open the door to her office, a patient rushes to thank her for support. Some time later the patient's daughter drops in to do the same. Another visitor wants her to visit her mother in the hospital.

Having been through chemotherapy herself, Neerja Malik finds it easy to speak to shattered patients and their families about cancer.

An aerobics enthusiast, she ignored a twinge below her armpit until it returned several times to bother her. Diagnosed as breast cancer she underwent chemotherapy when her twins were seven years old. Soon after that an uncle suggested that she talk to his friend who was admitted for cancer to Apollo Hospital in Chennai. And then, nurses in the hospital sought her out to speak to other patients.

The voluntary effort took concrete shape after she was diagnosed with cancer in the other breast six years later. Alert to changes the second time around, she was prepared for the diagnosis. But she must live with a broken rib bone that cannot be set right due to the amount of radiation given to her. “Even a graft from another part of the body will not help heal the bone,” she says. It has denied her the ability to exercise but that is a minor irritant she insists.

Cancer is scary because of the dreadful stories spun around it, she says. “A person with a positive and correct attitude doesn't have to be bogged down with fear. Fear is all about False Emotions Appearing Real,” she says.

Her family pampered her and it helped her get through the treatment, she says. In turn, she dispels fear of chemotherapy in patients referred to her. “I always like to talk to them before chemo so that I can prepare them for it. We have made a CD on chemo with information from doctors and patients that I give during counselling,” she says. She has held the hands of family members as they struggled with the truth that their loved one was slipping away.

Sometimes most of her conversations are over the phone. “I tell them that they are going to help me in my work. I tell them to join the support group.” Though very few have returned to become counsellors, she says she is happy that she has been able to put a smile back on the devastated faces that she encountered when she entered the hospital room.

Thursday, December 24, 2009

INDIA:GOA DOCTOR CURE FOR BREAST CANCER

Now, no amputation to cure breast cancers



A Goa-based doctor has invented a technology that can save women from amputating their cancer-infested breasts.

“The treatment, known as the Targeted Intra-operative Radiotherapy (TARGIT), can cure the fatal disease in just 25 minutes,” Jayant Vaidya, who is currently placed in UK, said.

TARGIT treats the tumour by delivering radiotherapy within the breast. The patient can go home the same day the surgery is conducted, he said.

Dr. Vaidya, who began his research during his stint at Tata Memorial hospital in Mumbai, later pursued it in University College at London.

He has also worked on Intra-beam machine used for brain treatment. “The machine was developed for application on breast in 1996-98,” he said